Cell death plays an essential role in many developmental and immune responses. Programmed cell death involves active cell decisions and is called “apoptosis”. Accidental death during injury is called “necrosis”.
Some methods of studying apoptosis rely on detection of DNA fragments produced by Apoptotic cells, such as “TUNEL” staining. Apoptosis is largely regulated by a family of proteins called caspases (cysteine aspartate-specific protease).
Extrinsic (receptor mediated) pathway
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